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Diseases	Field	Query

Alzheimer disease
Amyotrophic lateral sclerosis
Autism
Bipolar disorder
COXPD
Cancer
Cardiovascular diseases
Diabetes mellitus, type II
Epilepsy
Farber lipogranulomatosis
Inflammatory bowel disease
Lung disease
Major depressive disorder
Multiple sclerosis
Muscular atrophy
Neutropenia, severe congenital
Other
Parkinson disease
Post-traumatic stress disorder
Postpartum depression
Rare disease
Schizophrenia

	Field	Term

General Information:

Id:	4,068 (click here to show other Interactions for entry)
Diseases:	Alzheimer disease - [OMIM]
Organism:	Mus musculus
Organism Model:	C57BL/6 mouse
Tissue/Cell line:	BTO:0003037 HT-22 cell
Publication type:	article
Reference:	Xie L et al.(2013) Methylene blue induces macroautophagy through 5 adenosine monophosphate-activated protein kinase pathway to protect neurons from serum deprivation Front Cell Neurosci 7: 56 [PMID: 23653592]

Interaction Information:

Comment	Methylene blue induces macroautophagy via, at partially, AMPK signaling. Both AMPKalpha and AMPKbeta1/2 protein levels were increased in vitro.
Formal Description Interaction-ID: 41919	drug/chemical compound Methylene blue increases_expression of gene/protein PRKAB2 in vitro
Drugbank entries	Show/Hide entries for PRKAB2
Drugbank DB00131	Adenosine monophosphate activator PRKAB2
Drugbank DB00131	Adenosine monophosphate activator PRKAB2

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