General Information:

Id: 4,062 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
BTO:0000793 SH-SY5Y cell
article
Reference: Lira-De Leon KI et al.(2013) Molecular mechanism of tau aggregation induced by anionic and cationic dyes J. Alzheimers Dis. 35: 319-334 [PMID: 23435411]

Interaction Information:

Comment Anionic dyes such as Congo Red, Thiazine Red, and Thioflavin S are able to induce tau fibrillization in SH-SY5Y cells. These tau aggregates were not observed when the Methylene Blue dye was added to the cell culture.
Formal Description
Interaction-ID: 41875

drug/chemical compound

Methylene blue

decreases_activity of

drug/chemical compound

Congo red

Comment Anionic dyes such as Congo Red, Thiazine Red, and Thioflavin S are able to induce tau fibrillization in SH-SY5Y cells. These tau aggregates were not observed when the Methylene Blue dye was added to the cell culture.
Formal Description
Interaction-ID: 41876

drug/chemical compound

Methylene blue

decreases_activity of

drug/chemical compound

Thiazine red

Comment Anionic dyes such as Congo Red, Thiazine Red, and Thioflavin S are able to induce tau fibrillization in SH-SY5Y cells. These tau aggregates were not observed when the Methylene Blue dye was added to the cell culture.
Formal Description
Interaction-ID: 41877

drug/chemical compound

Methylene blue

decreases_activity of

drug/chemical compound

Thioflavin S