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Diseases	Field	Query

Alzheimer disease
Amyotrophic lateral sclerosis
Autism
Bipolar disorder
COXPD
Cancer
Cardiovascular diseases
Diabetes mellitus, type II
Epilepsy
Farber lipogranulomatosis
Inflammatory bowel disease
Lung disease
Major depressive disorder
Multiple sclerosis
Muscular atrophy
Neutropenia, severe congenital
Other
Parkinson disease
Post-traumatic stress disorder
Postpartum depression
Rare disease
Schizophrenia

	Field	Term

General Information:

Id:	4,062
Diseases:	Alzheimer disease - [OMIM]
Organism:	Homo sapiens
Tissue/Cell line:	BTO:0000793 SH-SY5Y cell
Publication type:	article
Reference:	Lira-De Leon KI et al.(2013) Molecular mechanism of tau aggregation induced by anionic and cationic dyes J. Alzheimers Dis. 35: 319-334 [PMID: 23435411]

Interaction Information:

Comment	Anionic dyes such as Congo Red, Thiazine Red, and Thioflavin S are able to induce tau fibrillization in SH-SY5Y cells incubated with each dye for seven days.
Formal Description Interaction-ID: 41867	drug/chemical compound Congo red increases_quantity of phenotype tau protein deposits in SH-SY5Y cells

Comment	Anionic dyes such as Congo Red, Thiazine Red, and Thioflavin S are able to induce tau fibrillization in SH-SY5Y cells incubated with each dye for seven days.
Formal Description Interaction-ID: 41871	drug/chemical compound Thiazine red increases_quantity of phenotype tau protein deposits in SH-SY5Y cells

Comment	Anionic dyes such as Congo Red, Thiazine Red, and Thioflavin S are able to induce tau fibrillization in SH-SY5Y cells incubated with each dye for seven days.
Formal Description Interaction-ID: 41872	drug/chemical compound Thioflavin S increases_quantity of phenotype tau protein deposits in SH-SY5Y cells

Comment	Anionic dyes such as Congo Red, Thiazine Red, and Thioflavin S are able to induce tau fibrillization in SH-SY5Y cells. These tau aggregates were not observed when the Methylene Blue dye was added to the cell culture.
Formal Description Interaction-ID: 41875	drug/chemical compound Methylene blue decreases_activity of drug/chemical compound Congo red

Comment	Anionic dyes such as Congo Red, Thiazine Red, and Thioflavin S are able to induce tau fibrillization in SH-SY5Y cells. These tau aggregates were not observed when the Methylene Blue dye was added to the cell culture.
Formal Description Interaction-ID: 41876	drug/chemical compound Methylene blue decreases_activity of drug/chemical compound Thiazine red

Comment	Anionic dyes such as Congo Red, Thiazine Red, and Thioflavin S are able to induce tau fibrillization in SH-SY5Y cells. These tau aggregates were not observed when the Methylene Blue dye was added to the cell culture.
Formal Description Interaction-ID: 41877	drug/chemical compound Methylene blue decreases_activity of drug/chemical compound Thioflavin S

Comment	Tau can interact with anionic dyes in SH-SY5Y cells.
Formal Description Interaction-ID: 41888	gene/protein MAPT interacts (colocalizes) with drug/chemical compound Anionic dye in SH-SY5Y cell

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