General Information:

Id: 4,061
Diseases: Alzheimer disease - [OMIM]
Mus musculus
P301L Tau transgenic mouse
article
Reference: Hosokawa M et al.(2012) Methylene blue reduced abnormal tau accumulation in P301L tau transgenic mice PLoS ONE 7 [PMID: 23285020]

Interaction Information:

Comment Methylene blue (MB), a type of phenothiazine, reduced abnormal Tau accumulation in P301L Tau transgenic mice and could be a potential treatment for tauopathy.
Formal Description
Interaction-ID: 41842

drug/chemical compound

Methylene blue

decreases_quantity of

in P301L Tau transgenic mice
Comment There was a significant reduction in the levels of total tau and phosphorylated tau in MB-treated mice.
Formal Description
Interaction-ID: 41864

drug/chemical compound

Methylene blue

decreases_quantity of

gene/protein

MAPT

Comment There was a significant reduction in the levels of total tau and phosphorylated tau in MB-treated mice.
Formal Description
Interaction-ID: 41865

drug/chemical compound

Methylene blue

decreases_quantity of

protein modification

MAPT-phos