General Information:

Id: 404 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Mus musculus
SOD1G93A transgenic mouse, transfected with human SOD1G93A
BTO:0000078 microglia
article
Reference: D'Ambrosi N et al.(2009) The proinflammatory action of microglial P2 receptors is enhanced in SOD1 models for amyotrophic lateral sclerosis J. Immunol. 183: 4648-4656 [PMID: 19734218]

Interaction Information:

Comment Immortalized hSOD1-G93A transgenic cells exhibit significantly higher basal expression of COX-2. The addition of extracellular ATP and BzATP (2'-3'-O-(benzoyl-benzoyl) ATP) increased COX-2 content in immortalized and primary hSOD1-G93A cells.
Formal Description
Interaction-ID: 1735

gene/protein mutant

SOD1-p.G93A

increases_quantity of

gene/protein

PTGS2

in immortalized microglia
Drugbank entries Show/Hide entries for PTGS2