General Information:

Id: 404 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Mus musculus
SOD1G93A transgenic mouse, transfected with human SOD1G93A
BTO:0000078 microglia
article
Reference: D'Ambrosi N et al.(2009) The proinflammatory action of microglial P2 receptors is enhanced in SOD1 models for amyotrophic lateral sclerosis J. Immunol. 183: 4648-4656 [PMID: 19734218]

Interaction Information:

Comment Overexpression of hSOD1-G93A is not sufficient to preactivate microglial cells to produce pro-IL-1-beta even after treatment with either ATP, BzATP (2'-3'-O-(benzoyl-benzoyl) ATP) or UDP (uridine diphosphate).
Formal Description
Interaction-ID: 1733

gene/protein mutant

SOD1-p.G93A

NOT affects_expression of

gene/protein

IL1B

in immortalized microglia
Drugbank entries Show/Hide entries for IL1B