General Information:

Id: 404 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Mus musculus
SOD1G93A transgenic mouse, transfected with human SOD1G93A
BTO:0000078 microglia
article
Reference: D'Ambrosi N et al.(2009) The proinflammatory action of microglial P2 receptors is enhanced in SOD1 models for amyotrophic lateral sclerosis J. Immunol. 183: 4648-4656 [PMID: 19734218]

Interaction Information:

Comment Under basal conditions, the expression of TNF-alpha was increased in immortalized hSOD1-G93A microglia, with respect to nontransgenic cells. The addition of extracellular ATP and BzATP (2'-3'-O-(benzoyl-benzoyl) ATP) increased TNF-alpha content in all cases, but with a higher level of induction in immortalized and primary hSOD1-G93A cells.
Formal Description
Interaction-ID: 1732

gene/protein mutant

SOD1-p.G93A

increases_expression of

gene/protein

TNF

in immortalized microglia
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