General Information:

Id: 404 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Mus musculus
SOD1G93A transgenic mouse, transfected with human SOD1G93A
BTO:0000078 microglia
article
Reference: D'Ambrosi N et al.(2009) The proinflammatory action of microglial P2 receptors is enhanced in SOD1 models for amyotrophic lateral sclerosis J. Immunol. 183: 4648-4656 [PMID: 19734218]

Interaction Information:

Comment There was an increase for P2X7 and P2Y6 mRNAs in immortalized hSOD1-G93A cells vs nt cells, whereas in primary hSOD1-G93A microglia only P2Y6 mRNA was significantly up-regulated. ATP, BzATP, and UDP are ligands known to activate these P2 receptors.
Formal Description
Interaction-ID: 1724

gene/protein mutant

SOD1-p.G93A

increases_expression of

gene/protein

P2RX7

in immortalized microglia