General Information:

Id: 404 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Mus musculus
SOD1G93A transgenic mouse, transfected with human SOD1G93A
BTO:0000078 microglia
article
Reference: D'Ambrosi N et al.(2009) The proinflammatory action of microglial P2 receptors is enhanced in SOD1 models for amyotrophic lateral sclerosis J. Immunol. 183: 4648-4656 [PMID: 19734218]

Interaction Information:

Comment The addition of extracellular ATP and BzATP (the most effective agonist) increased TNF-alpha content in all cases, but with a higher level of induction in immortalized and primary hSOD1-G93A cells. In general, BzATP was always more potent than ATP in increasing overall TNF-alpha content, with maximum levels reached in ALS-linked immortalized and primary cells.
Formal Description
Interaction-ID: 13546

drug/chemical compound

3'-O-(4-Benzoyl)benzoyl ATP

increases_quantity of

gene/protein

TNF

in immortalized and primary microglia
Drugbank entries Show/Hide entries for TNF