General Information:

Id: 403
Diseases: Parkinson disease
Rattus norvegicus
BTO:0000142 brain
article
Reference: Ren Y et al.(2003) Parkin binds to alpha/beta tubulin and increases their ubiquitination and degradation J. Neurosci. 8: 3316-3324 [PMID: 12716939]

Interaction Information:

Comment Parkin coassembles with microtubules in rat brain lysates.
Formal Description
Interaction-ID: 1731

gene/protein

PRKN

interacts (colocalizes) with

cellular component

microtubule

Comment Parkin binds to alpha and beta tubulin. Binding is not affected by colchicine treatment, indicating that parkin binds to tubulin alpha/beta heterodimers.
Formal Description
Interaction-ID: 1734

gene/protein

PRKN

interacts (colocalizes) with

gene/protein

TUBB

Drugbank entries Show/Hide entries for TUBB
Comment Parkin binds to alpha and beta tubulin. Binding is not affected by colchicine treatment, indicating that parkin binds to tubulin alpha/beta heterodimers.
Formal Description
Interaction-ID: 1736

gene/protein

PRKN

interacts (colocalizes) with

gene/protein

TUBA

Comment Parkin binds to alpha and beta tubulin. Binding is not affected by colchicine treatment, indicating that parkin binds to tubulin alpha/beta heterodimers.
Formal Description
Interaction-ID: 1737

gene/protein

PRKN

interacts (colocalizes) with

complex/PPI

Alpha/beta-tubulin complex

Comment Parkin enhances ubiquitination of alpha and beta tubulin.
Formal Description
Interaction-ID: 1743

gene/protein

PRKN

increases_ubiquitination/sumoylation of

gene/protein

TUBB

Drugbank entries Show/Hide entries for TUBB
Comment Parkin enhances ubiquitination of alpha and beta tubulin.
Formal Description
Interaction-ID: 1744

gene/protein

PRKN

increases_ubiquitination/sumoylation of

gene/protein

TUBA