CIDeRGeneral Information:
| Id: | 4,016 |
| Diseases: |
Circadian rhythm
Colorectal cancer - [OMIM] |
| Homo sapiens | |
| BTO:0000195 CACO-2 cell | |
| article | |
| Reference: | Ballesta A et al.(2011) A combined experimental and mathematical approach for molecular-based optimization of irinotecan circadian delivery PLoS Comput. Biol. 7 [PMID: 21931543] |
Interaction Information:
| Comment | After cell synchronization with a serum shock defining Circadian Time (CT) 0, circadian rhythms with a period of 26 h 50 (SD 63 min) were observed in the mRNA expression of clock genes REV-ERBalpha, PER2, BMAL1, the drug target topoisomerase 1 (TOP1), the activation enzyme carboxylesterase 2 (CES2), the deactivation enzyme UDP-glucuronosyltransferase 1, polypeptide A1 (UGT1A1), and efflux transporters ABCB1, ABCC1, ABCC2 and ABCG2. |
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Formal Description Interaction-ID: 41241 |
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| Drugbank entries | Show/Hide entries for ABCC1 |
| Comment | After cell synchronization with a serum shock defining Circadian Time (CT) 0, circadian rhythms with a period of 26 h 50 (SD 63 min) were observed in the mRNA expression of clock genes REV-ERBalpha, PER2, BMAL1, the drug target topoisomerase 1 (TOP1), the activation enzyme carboxylesterase 2 (CES2), the deactivation enzyme UDP-glucuronosyltransferase 1, polypeptide A1 (UGT1A1), and efflux transporters ABCB1, ABCC1, ABCC2 and ABCG2. |
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Formal Description Interaction-ID: 41242 |
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| Drugbank entries | Show/Hide entries for ABCC2 |
| Comment | After cell synchronization with a serum shock defining Circadian Time (CT) 0, circadian rhythms with a period of 26 h 50 (SD 63 min) were observed in the mRNA expression of clock genes REV-ERBalpha, PER2, BMAL1, the drug target topoisomerase 1 (TOP1), the activation enzyme carboxylesterase 2 (CES2), the deactivation enzyme UDP-glucuronosyltransferase 1, polypeptide A1 (UGT1A1), and efflux transporters ABCB1, ABCC1, ABCC2 and ABCG2. |
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Formal Description Interaction-ID: 41243 |
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