General Information:

Id: 4,000 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Obesity - [OMIM]
Homo sapiens
article
Reference: Pietilainen KH et al.(2008) Global transcript profiles of fat in monozygotic twins discordant for BMI: pathways behind acquired obesity PLoS Med. 5: E51 [PMID: 18336063]

Interaction Information:

Comment Down-regulation of the genes encoding enzymes essential for NAD(P) synthesis (NMNAT2, NMNAT3, visfatin) was associated with downregulation of NAD-dependent transcription regulators, such as SIRT1, 3, and 7 histone deacetylases (HDAC5, SIN3A), induction of which is linked to calorie restriction and longevity.
Formal Description
Interaction-ID: 41068

disease

Obesity

decreases_expression of

gene/protein

SIRT1

in subcutaneous adipose tissue; in monozygotic twins discordant for obesity