General Information:

Id: 39 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type I - [OMIM]
Homo sapiens
NCI-H460 cell; BTO:0000007 HEK-293T cell
article
Reference: Yeung F et al.(2004) Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase EMBO J. 23: 2369-2380 [PMID: 15152190]

Interaction Information:

Comment SIRT1 directly interacts with RelA/p65.
Formal Description
Interaction-ID: 90

gene/protein

SIRT1

interacts (colocalizes) with

gene/protein

RELA

Drugbank entries Show/Hide entries for RELA
Comment Resveratrol upregulated endogenous Sirtuin activity in NSCLC cell lines.
Formal Description
Interaction-ID: 91

drug/chemical compound

Resveratrol

increases_activity of

gene/protein

SIRT1

Drugbank entries Show/Hide entries for Resveratrol
Comment SIRT1 inhibits NF-kappa-B transcription by directly deacetylating the RelA/p65 protein at lysine 310.
Formal Description
Interaction-ID: 93

gene/protein

SIRT1

decreases_activity of

Comment Overexpression of SIRT1 diminished p300-mediated acetylation of RelA/p65.
Formal Description
Interaction-ID: 95

gene/protein

SIRT1

decreases_activity of

gene/protein

EP300

if SIRT1 is overexpressed
Comment Tthe NAD-dependent SIRT1 deacetylates RelA/p65 directly at lysine residue 310.
Formal Description
Interaction-ID: 96

gene/protein

SIRT1

decreases_acetylation of

gene/protein

RELA

Drugbank entries Show/Hide entries for RELA