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Field	Query

Alzheimer disease
Amyotrophic lateral sclerosis
Autism
Bipolar disorder
COXPD
Cancer
Cardiovascular diseases
Diabetes mellitus, type II
Epilepsy
Farber lipogranulomatosis
Inflammatory bowel disease
Lung disease
Major depressive disorder
Multiple sclerosis
Muscular atrophy
Neutropenia, severe congenital
Other
Parkinson disease
Post-traumatic stress disorder
Postpartum depression
Rare disease
Schizophrenia

	Field	Term

General Information:

Id:	39 (click here to show other Interactions for entry)
Diseases:	Diabetes mellitus, type I - [OMIM]
Organism:	Homo sapiens
Tissue/Cell line:	NCI-H460 cell; BTO:0000007 HEK-293T cell
Publication type:	article
Reference:	Yeung F et al.(2004) Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase EMBO J. 23: 2369-2380 [PMID: 15152190]

Interaction Information:

Comment	SIRT1 directly interacts with RelA/p65.
Formal Description Interaction-ID: 90	gene/protein SIRT1 interacts (colocalizes) with gene/protein RELA
Drugbank entries	Show/Hide entries for RELA
Drugbank DB02836	Guanosine 5'-Diphosphate 2':3'-Cyclic Mo ... not specified relA
Drugbank DB04315	Guanosine-5'-Diphosphate not specified relA
Drugbank DB02836	Guanosine 5'-Diphosphate 2':3'-Cyclic Mo ... not specified relA
Drugbank DB04315	Guanosine-5'-Diphosphate not specified relA

Comment	Resveratrol upregulated endogenous Sirtuin activity in NSCLC cell lines.
Formal Description Interaction-ID: 91	drug/chemical compound Resveratrol increases_activity of gene/protein SIRT1
Drugbank entries	Show/Hide entries for Resveratrol
Drugbank DB02709	Resveratrol inhibitor PTGS1
Drugbank DB02709	Resveratrol not specified NQO2
Drugbank DB02709	Resveratrol inhibitor PTGS2
Drugbank DB02709	Resveratrol not specified CSNK2A1

Comment	SIRT1 inhibits NF-kappa-B transcription by directly deacetylating the RelA/p65 protein at lysine 310.
Formal Description Interaction-ID: 93	gene/protein SIRT1 decreases_activity of process positive regulation of NF-kappaB transcription factor activity

Comment	Overexpression of SIRT1 diminished p300-mediated acetylation of RelA/p65.
Formal Description Interaction-ID: 95	gene/protein SIRT1 decreases_activity of gene/protein EP300 if SIRT1 is overexpressed

Comment	Tthe NAD-dependent SIRT1 deacetylates RelA/p65 directly at lysine residue 310.
Formal Description Interaction-ID: 96	gene/protein SIRT1 decreases_acetylation of gene/protein RELA
Drugbank entries	Show/Hide entries for RELA
Drugbank DB02836	Guanosine 5'-Diphosphate 2':3'-Cyclic Mo ... not specified relA
Drugbank DB04315	Guanosine-5'-Diphosphate not specified relA
Drugbank DB02836	Guanosine 5'-Diphosphate 2':3'-Cyclic Mo ... not specified relA
Drugbank DB04315	Guanosine-5'-Diphosphate not specified relA

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