General Information:

Id: 3,991 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
male
db/db diabetic mouse
article
Reference: Connor SC et al.(2010) Integration of metabolomics and transcriptomics data to aid biomarker discovery in type 2 diabetes Mol Biosyst 6: 909-921 [PMID: 20567778]

Interaction Information:

Comment The thermodynamically irreversible reactions that are unique to liver (and kidney) gluconeogenesis (pyruvate carboxylase PC, phosphoenolpyruvate carboxykinase PCK1, fructose 1,6-bisphosphatase FBP1, and glucose 6-phosphatase G6PC) are all up-regulated in the liver of diabetic db/db mice.
Formal Description
Interaction-ID: 40913

increases_expression of

gene/protein

FBP1

in liver; in diabetic db/db mouse
Drugbank entries Show/Hide entries for FBP1