General Information:

Id: 397 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mus musculus
brain/neuron-specific insulin receptor knockout (NIRKO) mouse
Reference: Schubert M et al.(2004) Role for neuronal insulin resistance in neurodegenerative diseases Proc. Natl. Acad. Sci. U.S.A. 101: 3100-3105 [PMID: 14981233]

Interaction Information:

Comment Abolishing neuronal insulin signaling in NIRKO mice leads to major alterations in Akt and GSK3B phosphorylation and hyperphosphorylation of Tau protein at sites associated with neurodegenerative diseases. Altered insulin signaling in the brain leads to one of the hallmarks of Alzheimer's disease.
Formal Description
Interaction-ID: 1701

affects_activity of