General Information:

Id: 396 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Mus musculus
SOD1G93A transgenic mouse, transfected with human SOD1G93A
BTO:0000099 astrocyte
article
Reference: Kiaei M et al.(2006) Thalidomide and lenalidomide extend survival in a transgenic mouse model of amyotrophic lateral sclerosis. J. Neurosci. 26: 2467-2473 [PMID: 16510725]

Interaction Information:

Comment There is an increase of TNF-alpha and FasL immunoreactivity in lumbar spinal cord sections of ALS patients and G93A transgenic mice. TNF-alpha staining also occurred in actrocytes at 110 d of age.
Formal Description
Interaction-ID: 1638

gene/protein mutant

SOD1-p.G93A

increases_quantity of

gene/protein

TNF

in astrocytes; at 110 days of age
Drugbank entries Show/Hide entries for TNF