General Information:

Id: 3,938 (click here to show other Interactions for entry)
Diseases: Multiple sclerosis - [OMIM]
Mammalia
EAE (experimental autoimmune encephalomyelitis) mouse model
article
Reference: Min K et al.(2007) Immunosuppressive effect of silibinin in experimental autoimmune encephalomyelitis Arch. Pharm. Res. 30: 1265-1272 [PMID: 18038905]

Interaction Information:

Comment Silibinin down-regulates the secretion of pro-inflammatory Th1 cytokines (cytokines produced by Th1 cells) and up-regulates the anti-inflammatory Th2 cytokines (cytokines produced by Th2 cells) in vitro and also dose-dependently inhibited the production of Th1 cytokines ex vivo.
Formal Description
Interaction-ID: 40002

drug/chemical compound

Silibinin

affects_quantity of

gene/protein

Cytokine

secretion of pro-inflammatory Th1 cytokines and anti-inflammatory Th2 cytokines is regulated in vitro