General Information:

Id: 3,938 (click here to show other Interactions for entry)
Diseases: Multiple sclerosis - [OMIM]
Mammalia
EAE (experimental autoimmune encephalomyelitis) mouse model
article
Reference: Min K et al.(2007) Immunosuppressive effect of silibinin in experimental autoimmune encephalomyelitis Arch. Pharm. Res. 30: 1265-1272 [PMID: 18038905]

Interaction Information:

Comment Silibinin significantly reduced the histological signs of demyelination and inflammation in EAE (experimental autoimmune encephalomyelitis) MS animal models.
Formal Description
Interaction-ID: 39986

drug/chemical compound

Silibinin

decreases_activity of

phenotype

experimental autoimmune encephalomyelitis

in MS animal models
Comment Silibinin significantly reduced the histological signs of demyelination and inflammation in EAE (experimental autoimmune encephalomyelitis) MS animal models.
Formal Description
Interaction-ID: 39987

drug/chemical compound

Silibinin

decreases_activity of

in MS animal models
Comment Silibinin significantly reduced the histological signs of demyelination and inflammation in EAE (experimental autoimmune encephalomyelitis) MS animal models.
Formal Description
Interaction-ID: 39988

drug/chemical compound

Silibinin

decreases_activity of

phenotype

demyelination

in MS animal models
Comment Silibinin down-regulates the secretion of pro-inflammatory Th1 cytokines (cytokines produced by Th1 cells) and up-regulates the anti-inflammatory Th2 cytokines (cytokines produced by Th2 cells) in vitro and also dose-dependently inhibited the production of Th1 cytokines ex vivo.
Formal Description
Interaction-ID: 40002

drug/chemical compound

Silibinin

affects_quantity of

gene/protein

Cytokine

secretion of pro-inflammatory Th1 cytokines and anti-inflammatory Th2 cytokines is regulated in vitro