General Information:

Id: 3,922 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Homo sapiens
BTO:0000093 MCF-7 cell
article
Reference: Duncan RE et al.(2005) Regulation of HMG-CoA reductase in MCF-7 cells by genistein, EPA, and DHA, alone and in combination with mevastatin Cancer Lett. 224: 221-228 [PMID: 15914273]

Interaction Information:

Comment DHA also significantly attenuated the induction of HMG-CoA reductase activity by mevastatin in MCF-7 cells. Reductase activity was 15% lower in cells treated concomitantly with DHA and mevastatin, compared to cells treated with mevastatin alone. The magnitude of this down-regulation, however, was smaller than that observed in cells grown in the absence of mevastatin, in which DHA produced an 30% reduction in HMG-CoA reductase activity. DHA caused no change in reductase mRNA in mevastatin-treated cells, indicating that regulation of reductase activity by DHA was mediated entirely at a post-transcriptional level. Unlike DHA or genistein, EPA produced no change in HMG-CoA reductase in mevastatin-treated cells.
Formal Description
Interaction-ID: 39833

drug/chemical compound

Eicosapentaenoic acid

NOT decreases_activity of

drug/chemical compound

Mevastatin

in MCF-7 breast cancer cells
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