CIDeRGeneral Information:
| Id: | 3,922 (click here to show other Interactions for entry) |
| Diseases: |
Diabetes mellitus, type II
- [OMIM]
Insulin resistance |
| Homo sapiens | |
| BTO:0000093 MCF-7 cell | |
| article | |
| Reference: | Duncan RE et al.(2005) Regulation of HMG-CoA reductase in MCF-7 cells by genistein, EPA, and DHA, alone and in combination with mevastatin Cancer Lett. 224: 221-228 [PMID: 15914273] |
Interaction Information:
| Comment | Treatment with the isoflavone genistein or the long chain n-3 PUFAs DHA or EPA significantly inhibits the proliferation of MCF-7 human breast cancer cells in a concentration-dependent manner. Under the same treatment conditions, genistein, EPA and DHA also down-regulated MCF-7 cell HMG-CoA reductase as measured by the enzyme activity of cell-free supernatants. A dose-dependent response was seen for genistein on HMG-CoA reductase activity. |
|
Formal Description Interaction-ID: 39809 |
drug/chemical compound decreases_activity of process |
| Drugbank entries | Show/Hide entries for Genistein |
| Comment | Treatment with the isoflavone genistein or the long chain n-3 PUFAs DHA or EPA significantly inhibits the proliferation of MCF-7 human breast cancer cells in a concentration-dependent manner. Under the same treatment conditions, genistein, EPA and DHA also down-regulated MCF-7 cell HMG-CoA reductase as measured by the enzyme activity of cell-free supernatants. A dose-dependent response was seen for genistein on HMG-CoA reductase activity. |
|
Formal Description Interaction-ID: 39810 |
drug/chemical compound decreases_activity of process |
| Comment | Treatment with the isoflavone genistein or the long chain n-3 PUFAs DHA or EPA significantly inhibits the proliferation of MCF-7 human breast cancer cells in a concentration-dependent manner. Under the same treatment conditions, genistein, EPA and DHA also down-regulated MCF-7 cell HMG-CoA reductase as measured by the enzyme activity of cell-free supernatants. A dose-dependent response was seen for genistein on HMG-CoA reductase activity. |
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Formal Description Interaction-ID: 39823 |
drug/chemical compound decreases_activity of process |