General Information:

Id: 3,922 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Homo sapiens
BTO:0000093 MCF-7 cell
article
Reference: Duncan RE et al.(2005) Regulation of HMG-CoA reductase in MCF-7 cells by genistein, EPA, and DHA, alone and in combination with mevastatin Cancer Lett. 224: 221-228 [PMID: 15914273]

Interaction Information:

Comment Treatment with the isoflavone genistein or the long chain n-3 PUFAs DHA or EPA significantly inhibits the proliferation of MCF-7 human breast cancer cells in a concentration-dependent manner. Under the same treatment conditions, genistein, EPA and DHA also down-regulated MCF-7 cell HMG-CoA reductase as measured by the enzyme activity of cell-free supernatants. A dose-dependent response was seen for genistein on HMG-CoA reductase activity.
Formal Description
Interaction-ID: 39810

drug/chemical compound

Docosahexaenoic acid

decreases_activity of

in MCF-7 breast cancer cells