CIDeRGeneral Information:
| Id: | 391 (click here to show other Interactions for entry) |
| Diseases: |
Amyotrophic lateral sclerosis
|
| Mus musculus | |
| SOD1(G93A) transgenic mouse | |
| BTO:0001279 spinal cord; BTO:0000312 motoneuron | |
| article | |
| Reference: | Kiaei M et al.(2006) Thalidomide and lenalidomide extend survival in a transgenic mouse model of amyotrophic lateral sclerosis J. Neurosci. 26: 2467-2473 [PMID: 16510725] |
Interaction Information:
| Comment | There is an increase of TNF-alpha and FasL immunoreactivity in lumbar spinal cord sections of ALS patients and G93A transgenic mice. At 60 d, motor neurons from G93A mice with a healthy appearance were stained with TNF-alpha moderately, and immunoreactivity became more intense at 90 and 110 d. |
|
Formal Description Interaction-ID: 1608 |
gene/protein mutant increases_quantity of gene/protein |
| Drugbank entries | Show/Hide entries for TNF |
| Comment | TNF-alpha mRNA was increased 10-fold in G93A SOD1 mice compared with control littermates. Thalidomide and lenalidomide treatment reduced TNF-alpha mRNA significantly. |
|
Formal Description Interaction-ID: 1626 |
gene/protein mutant increases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for TNF |
| Comment | TNF-alpha mRNA was increased 10-fold in G93A SOD1 mice compared with control littermates. Thalidomide and lenalidomide treatment reduced TNF-alpha mRNA significantly. |
|
Formal Description Interaction-ID: 1635 |
drug/chemical compound decreases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for Thalidomide or TNF |
| Comment | TNF-alpha mRNA was increased 10-fold in G93A SOD1 mice compared with control littermates. Thalidomide and lenalidomide treatment reduced TNF-alpha mRNA significantly. |
|
Formal Description Interaction-ID: 1636 |
drug/chemical compound decreases_expression of gene/protein |
| Drugbank entries | Show/Hide entries for Lenalidomide or TNF |