General Information:

Id: 391 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Mus musculus
SOD1(G93A) transgenic mouse
BTO:0001279 spinal cord; BTO:0000312 motoneuron
article
Reference: Kiaei M et al.(2006) Thalidomide and lenalidomide extend survival in a transgenic mouse model of amyotrophic lateral sclerosis J. Neurosci. 26: 2467-2473 [PMID: 16510725]

Interaction Information:

Comment TNF-alpha mRNA was increased 10-fold in G93A SOD1 mice compared with control littermates. Thalidomide and lenalidomide treatment reduced TNF-alpha mRNA significantly.
Formal Description
Interaction-ID: 1636

drug/chemical compound

Lenalidomide

decreases_expression of

gene/protein

TNF

in spinal cord motor neurons; in SOD1(G93A) transgenic mice
Drugbank entries Show/Hide entries for Lenalidomide or TNF