General Information:

Id: 391 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Mus musculus
SOD1(G93A) transgenic mouse
BTO:0001279 spinal cord; BTO:0000312 motoneuron
article
Reference: Kiaei M et al.(2006) Thalidomide and lenalidomide extend survival in a transgenic mouse model of amyotrophic lateral sclerosis J. Neurosci. 26: 2467-2473 [PMID: 16510725]

Interaction Information:

Comment There is an increase of TNF-alpha and FasL immunoreactivity in lumbar spinal cord sections of ALS patients and G93A transgenic mice. At 60 d, motor neurons from G93A mice with a healthy appearance were stained with TNF-alpha moderately, and immunoreactivity became more intense at 90 and 110 d.
Formal Description
Interaction-ID: 1608

gene/protein mutant

SOD1-p.G93A

increases_quantity of

gene/protein

TNF

in spinal cord motor neurons; especially at stage 90-110 days
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