General Information:

Id: 3,917 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Homo sapiens
article
Reference: Koh KK et al.(2010) Atorvastatin causes insulin resistance and increases ambient glycemia in hypercholesterolemic patients J. Am. Coll. Cardiol. 55: 1209-1216 [PMID: 20298928]

Interaction Information:

Comment Atorvastatin 10, 20, 40, and 80 mg significantly reduced LDL cholesterol and apolipoprotein B levels after 2 months of therapy when compared with either baseline or placebo. Atorvastatin 10, 20, 40, and 80 mg significantly increased fasting plasma insulin and glycated hemoglobin levels when compared with either baseline or placebo. Atorvastatin 10, 20, 40, and 80 mg decreased insulin sensitivity when compared with either baseline or placebo. Despite beneficial reductions in LDL cholesterol and apolipoprotein B, atorvastatin treatment resulted in significant increases in fasting insulin and glycated hemoglobin levels consistent with insulin resistance and increased ambient glycemia in hypercholesterolemic patients.
Formal Description
Interaction-ID: 39771

drug/chemical compound

Atorvastatin

increases_activity of

phenotype

decreased insulin sensitivity

Drugbank entries Show/Hide entries for Atorvastatin