General Information:

Id: 3,892 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mammalia
article
Reference: Ringseis R et al.(2012) Regulation of Genes Involved in Carnitine Homeostasis by PPARalpha across Different Species (Rat, Mouse, Pig, Cattle, Chicken, and Human) PPAR Res 2012 [PMID: 23150726]

Interaction Information:

Comment It could be convincingly demonstrated that the mouse genes encoding the carnitine transporter novel organic cation transporter 2 (OCTN2/SLC22A5) and two enzymes of the carnitine biosynthetic pathway, gamma-butyrobetaine dioxygenase (BBOX1) and 4-trimethylaminobutyraldehyde dehydrogenase (ALDH9A1), are direct PPARalpha target genes as evidenced by the identification of functional peroxysome proliferator responsive elements (PPRE) within the regulatory region of the respective genes.
Formal Description
Interaction-ID: 39382

gene/protein

PPARA

increases_expression of

gene/protein

BBOX1

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