General Information:

Id: 3,877 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Homo sapiens
male
article
Reference: Jula A et al.(2005) Effects of diet and simvastatin on fatty acid composition in hypercholesterolemic men: a randomized controlled trial Arterioscler. Thromb. Vasc. Biol. 25: 1952-1959 [PMID: 16020749]

Interaction Information:

Comment Simvastatin increased the proportion of long-chain fatty acids (C20-22) from total fatty acids by 9.0%, and the ratios of stearic to palmitic acid (reflecting elongase activity) by 7.6%, gamma-linolenic to linoleic acid (reflecting Delta6 desaturase activity) by 17.0%, and the ratios of arachidonic to dihomo-gamma-linolenic and eicosapentaenoic to eicosatetraenoic acid, both reflecting Delta5 desaturase activity, by 10.0% and 26.9%, respectively.
Formal Description
Interaction-ID: 39089

drug/chemical compound

Simvastatin

increases_activity of

gene/protein

FADS1

Drugbank entries Show/Hide entries for Simvastatin or FADS1