General Information:

Id: 3,877 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Homo sapiens
male
article
Reference: Jula A et al.(2005) Effects of diet and simvastatin on fatty acid composition in hypercholesterolemic men: a randomized controlled trial Arterioscler. Thromb. Vasc. Biol. 25: 1952-1959 [PMID: 16020749]

Interaction Information:

Comment Simvastatin decreased serum total fatty acid concentration by 13.0% and the concentrations of several fatty acids, including alpha-linolenic, eicosatetraenoic (C20:4 n-3), and docosahexaenoic (C22:6 n-3) acid. It decreased the proportion of myristic acid (C14:0) from total fatty acids by 11.5%, and that of palmitic, linoleic (C18:2 n-6) and alpha-linolenic acid by 2.0%, 5.3%, and 6.8%, respectively. The proportions of gamma-linolenic (C18:3 n-6), dihomo-gamma-linolenic (C20:3 n-6), and arachidonic acid (C20:4 n-6) from total fatty acids in serum were increased by 11.1%, 4.2%, and 14.2%, respectively. The effects of dietary treatment and simvastatin on the proportions of serum fatty acids were independent and additive.
Formal Description
Interaction-ID: 39079

drug/chemical compound

Simvastatin

increases_quantity of

drug/chemical compound

Eicosatrienoic acid

in blood serum
Drugbank entries Show/Hide entries for Simvastatin