General Information:

Id: 3,877 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Homo sapiens
male
article
Reference: Jula A et al.(2005) Effects of diet and simvastatin on fatty acid composition in hypercholesterolemic men: a randomized controlled trial Arterioscler. Thromb. Vasc. Biol. 25: 1952-1959 [PMID: 16020749]

Interaction Information:

Comment Simvastatin decreased serum total fatty acid concentration by 13.0% and the concentrations of several fatty acids, including alpha-linolenic, eicosatetraenoic (C20:4 n-3), and docosahexaenoic (C22:6 n-3) acid. It decreased the proportion of myristic acid (C14:0) from total fatty acids by 11.5%, and that of palmitic, linoleic (C18:2 n-6) and alpha-linolenic acid by 2.0%, 5.3%, and 6.8%, respectively. The proportions of gamma-linolenic (C18:3 n-6), dihomo-gamma-linolenic (C20:3 n-6), and arachidonic acid (C20:4 n-6) from total fatty acids in serum were increased by 11.1%, 4.2%, and 14.2%, respectively. The effects of dietary treatment and simvastatin on the proportions of serum fatty acids were independent and additive.
Formal Description
Interaction-ID: 39067

drug/chemical compound

Simvastatin

increases_activity of

in blood serum
Drugbank entries Show/Hide entries for Simvastatin
Comment Simvastatin decreased serum total fatty acid concentration by 13.0% and the concentrations of several fatty acids, including alpha-linolenic, eicosatetraenoic (C20:4 n-3), and docosahexaenoic (C22:6 n-3) acid. It decreased the proportion of myristic acid (C14:0) from total fatty acids by 11.5%, and that of palmitic, linoleic (C18:2 n-6) and alpha-linolenic acid by 2.0%, 5.3%, and 6.8%, respectively. The proportions of gamma-linolenic (C18:3 n-6), dihomo-gamma-linolenic (C20:3 n-6), and arachidonic acid (C20:4 n-6) from total fatty acids in serum were increased by 11.1%, 4.2%, and 14.2%, respectively. The effects of dietary treatment and simvastatin on the proportions of serum fatty acids were independent and additive.
Formal Description
Interaction-ID: 39070

drug/chemical compound

Simvastatin

decreases_quantity of

drug/chemical compound

alpha-Linolenic acid

in blood serum
Drugbank entries Show/Hide entries for Simvastatin or alpha-Linolenic acid
Comment Simvastatin decreased serum total fatty acid concentration by 13.0% and the concentrations of several fatty acids, including alpha-linolenic, eicosatetraenoic (C20:4 n-3), and docosahexaenoic (C22:6 n-3) acid. It decreased the proportion of myristic acid (C14:0) from total fatty acids by 11.5%, and that of palmitic, linoleic (C18:2 n-6) and alpha-linolenic acid by 2.0%, 5.3%, and 6.8%, respectively. The proportions of gamma-linolenic (C18:3 n-6), dihomo-gamma-linolenic (C20:3 n-6), and arachidonic acid (C20:4 n-6) from total fatty acids in serum were increased by 11.1%, 4.2%, and 14.2%, respectively. The effects of dietary treatment and simvastatin on the proportions of serum fatty acids were independent and additive.
Formal Description
Interaction-ID: 39071

drug/chemical compound

Simvastatin

decreases_quantity of

drug/chemical compound

Eicosatetraenoic acid

in blood serum
Drugbank entries Show/Hide entries for Simvastatin
Comment Simvastatin decreased serum total fatty acid concentration by 13.0% and the concentrations of several fatty acids, including alpha-linolenic, eicosatetraenoic (C20:4 n-3), and docosahexaenoic (C22:6 n-3) acid. It decreased the proportion of myristic acid (C14:0) from total fatty acids by 11.5%, and that of palmitic, linoleic (C18:2 n-6) and alpha-linolenic acid by 2.0%, 5.3%, and 6.8%, respectively. The proportions of gamma-linolenic (C18:3 n-6), dihomo-gamma-linolenic (C20:3 n-6), and arachidonic acid (C20:4 n-6) from total fatty acids in serum were increased by 11.1%, 4.2%, and 14.2%, respectively. The effects of dietary treatment and simvastatin on the proportions of serum fatty acids were independent and additive.
Formal Description
Interaction-ID: 39072

drug/chemical compound

Simvastatin

decreases_quantity of

drug/chemical compound

Docosahexaenoic acid

in blood serum
Drugbank entries Show/Hide entries for Simvastatin
Comment Simvastatin decreased serum total fatty acid concentration by 13.0% and the concentrations of several fatty acids, including alpha-linolenic, eicosatetraenoic (C20:4 n-3), and docosahexaenoic (C22:6 n-3) acid. It decreased the proportion of myristic acid (C14:0) from total fatty acids by 11.5%, and that of palmitic, linoleic (C18:2 n-6) and alpha-linolenic acid by 2.0%, 5.3%, and 6.8%, respectively. The proportions of gamma-linolenic (C18:3 n-6), dihomo-gamma-linolenic (C20:3 n-6), and arachidonic acid (C20:4 n-6) from total fatty acids in serum were increased by 11.1%, 4.2%, and 14.2%, respectively. The effects of dietary treatment and simvastatin on the proportions of serum fatty acids were independent and additive.
Formal Description
Interaction-ID: 39073

drug/chemical compound

Simvastatin

decreases_quantity of

drug/chemical compound

Myristic acid

in blood serum
Drugbank entries Show/Hide entries for Simvastatin or Myristic acid
Comment Simvastatin decreased serum total fatty acid concentration by 13.0% and the concentrations of several fatty acids, including alpha-linolenic, eicosatetraenoic (C20:4 n-3), and docosahexaenoic (C22:6 n-3) acid. It decreased the proportion of myristic acid (C14:0) from total fatty acids by 11.5%, and that of palmitic, linoleic (C18:2 n-6) and alpha-linolenic acid by 2.0%, 5.3%, and 6.8%, respectively. The proportions of gamma-linolenic (C18:3 n-6), dihomo-gamma-linolenic (C20:3 n-6), and arachidonic acid (C20:4 n-6) from total fatty acids in serum were increased by 11.1%, 4.2%, and 14.2%, respectively. The effects of dietary treatment and simvastatin on the proportions of serum fatty acids were independent and additive.
Formal Description
Interaction-ID: 39074

drug/chemical compound

Simvastatin

decreases_quantity of

drug/chemical compound

Palmitic acid

in blood serum
Drugbank entries Show/Hide entries for Simvastatin or Palmitic acid
Comment Simvastatin decreased serum total fatty acid concentration by 13.0% and the concentrations of several fatty acids, including alpha-linolenic, eicosatetraenoic (C20:4 n-3), and docosahexaenoic (C22:6 n-3) acid. It decreased the proportion of myristic acid (C14:0) from total fatty acids by 11.5%, and that of palmitic, linoleic (C18:2 n-6) and alpha-linolenic acid by 2.0%, 5.3%, and 6.8%, respectively. The proportions of gamma-linolenic (C18:3 n-6), dihomo-gamma-linolenic (C20:3 n-6), and arachidonic acid (C20:4 n-6) from total fatty acids in serum were increased by 11.1%, 4.2%, and 14.2%, respectively. The effects of dietary treatment and simvastatin on the proportions of serum fatty acids were independent and additive.
Formal Description
Interaction-ID: 39075

drug/chemical compound

Simvastatin

decreases_quantity of

drug/chemical compound

Linoleic acid

in blood serum
Drugbank entries Show/Hide entries for Simvastatin
Comment Simvastatin decreased serum total fatty acid concentration by 13.0% and the concentrations of several fatty acids, including alpha-linolenic, eicosatetraenoic (C20:4 n-3), and docosahexaenoic (C22:6 n-3) acid. It decreased the proportion of myristic acid (C14:0) from total fatty acids by 11.5%, and that of palmitic, linoleic (C18:2 n-6) and alpha-linolenic acid by 2.0%, 5.3%, and 6.8%, respectively. The proportions of gamma-linolenic (C18:3 n-6), dihomo-gamma-linolenic (C20:3 n-6), and arachidonic acid (C20:4 n-6) from total fatty acids in serum were increased by 11.1%, 4.2%, and 14.2%, respectively. The effects of dietary treatment and simvastatin on the proportions of serum fatty acids were independent and additive.
Formal Description
Interaction-ID: 39076

drug/chemical compound

Simvastatin

decreases_quantity of

drug/chemical compound

alpha-Linolenic acid

in blood serum
Drugbank entries Show/Hide entries for Simvastatin or alpha-Linolenic acid
Comment Simvastatin decreased serum total fatty acid concentration by 13.0% and the concentrations of several fatty acids, including alpha-linolenic, eicosatetraenoic (C20:4 n-3), and docosahexaenoic (C22:6 n-3) acid. It decreased the proportion of myristic acid (C14:0) from total fatty acids by 11.5%, and that of palmitic, linoleic (C18:2 n-6) and alpha-linolenic acid by 2.0%, 5.3%, and 6.8%, respectively. The proportions of gamma-linolenic (C18:3 n-6), dihomo-gamma-linolenic (C20:3 n-6), and arachidonic acid (C20:4 n-6) from total fatty acids in serum were increased by 11.1%, 4.2%, and 14.2%, respectively. The effects of dietary treatment and simvastatin on the proportions of serum fatty acids were independent and additive.
Formal Description
Interaction-ID: 39077

drug/chemical compound

Simvastatin

increases_quantity of

drug/chemical compound

gamma-Linolenic acid

in blood serum
Drugbank entries Show/Hide entries for Simvastatin
Comment Simvastatin decreased serum total fatty acid concentration by 13.0% and the concentrations of several fatty acids, including alpha-linolenic, eicosatetraenoic (C20:4 n-3), and docosahexaenoic (C22:6 n-3) acid. It decreased the proportion of myristic acid (C14:0) from total fatty acids by 11.5%, and that of palmitic, linoleic (C18:2 n-6) and alpha-linolenic acid by 2.0%, 5.3%, and 6.8%, respectively. The proportions of gamma-linolenic (C18:3 n-6), dihomo-gamma-linolenic (C20:3 n-6), and arachidonic acid (C20:4 n-6) from total fatty acids in serum were increased by 11.1%, 4.2%, and 14.2%, respectively. The effects of dietary treatment and simvastatin on the proportions of serum fatty acids were independent and additive.
Formal Description
Interaction-ID: 39079

drug/chemical compound

Simvastatin

increases_quantity of

drug/chemical compound

Eicosatrienoic acid

in blood serum
Drugbank entries Show/Hide entries for Simvastatin
Comment Simvastatin decreased serum total fatty acid concentration by 13.0% and the concentrations of several fatty acids, including alpha-linolenic, eicosatetraenoic (C20:4 n-3), and docosahexaenoic (C22:6 n-3) acid. It decreased the proportion of myristic acid (C14:0) from total fatty acids by 11.5%, and that of palmitic, linoleic (C18:2 n-6) and alpha-linolenic acid by 2.0%, 5.3%, and 6.8%, respectively. The proportions of gamma-linolenic (C18:3 n-6), dihomo-gamma-linolenic (C20:3 n-6), and arachidonic acid (C20:4 n-6) from total fatty acids in serum were increased by 11.1%, 4.2%, and 14.2%, respectively. The effects of dietary treatment and simvastatin on the proportions of serum fatty acids were independent and additive.
Formal Description
Interaction-ID: 39086

drug/chemical compound

Simvastatin

increases_quantity of

drug/chemical compound

Arachidonic acid

in blood serum
Drugbank entries Show/Hide entries for Simvastatin or Arachidonic acid
Comment Simvastatin increased the proportion of long-chain fatty acids (C20-22) from total fatty acids by 9.0%, and the ratios of stearic to palmitic acid (reflecting elongase activity) by 7.6%, gamma-linolenic to linoleic acid (reflecting Delta6 desaturase activity) by 17.0%, and the ratios of arachidonic to dihomo-gamma-linolenic and eicosapentaenoic to eicosatetraenoic acid, both reflecting Delta5 desaturase activity, by 10.0% and 26.9%, respectively.
Formal Description
Interaction-ID: 39087

drug/chemical compound

Simvastatin

increases_activity of

gene/protein

ELOVL6

Drugbank entries Show/Hide entries for Simvastatin
Comment Simvastatin increased the proportion of long-chain fatty acids (C20-22) from total fatty acids by 9.0%, and the ratios of stearic to palmitic acid (reflecting elongase activity) by 7.6%, gamma-linolenic to linoleic acid (reflecting Delta6 desaturase activity) by 17.0%, and the ratios of arachidonic to dihomo-gamma-linolenic and eicosapentaenoic to eicosatetraenoic acid, both reflecting Delta5 desaturase activity, by 10.0% and 26.9%, respectively.
Formal Description
Interaction-ID: 39088

drug/chemical compound

Simvastatin

increases_activity of

gene/protein

FADS2

Drugbank entries Show/Hide entries for Simvastatin or FADS2
Comment Simvastatin increased the proportion of long-chain fatty acids (C20-22) from total fatty acids by 9.0%, and the ratios of stearic to palmitic acid (reflecting elongase activity) by 7.6%, gamma-linolenic to linoleic acid (reflecting Delta6 desaturase activity) by 17.0%, and the ratios of arachidonic to dihomo-gamma-linolenic and eicosapentaenoic to eicosatetraenoic acid, both reflecting Delta5 desaturase activity, by 10.0% and 26.9%, respectively.
Formal Description
Interaction-ID: 39089

drug/chemical compound

Simvastatin

increases_activity of

gene/protein

FADS1

Drugbank entries Show/Hide entries for Simvastatin or FADS1
Comment Increased formation of long-chain polyunsaturated fatty acids and their metabolites may contribute a substantial part of the pleiotropic effects of simvastatin.
Formal Description
Interaction-ID: 39093

drug/chemical compound

Simvastatin

increases_activity of

process

long-chain polyunsaturated fatty acid biosynthetic process

Drugbank entries Show/Hide entries for Simvastatin