General Information:

Id: 3,872 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mammalia
review
Reference: de Lorgeril M et al.(2013) Recent findings on the health effects of omega-3 fatty acids and statins, and their interactions: do statins inhibit omega-3 BMC Med 11: 5 [PMID: 23289647]

Interaction Information:

Comment A growing body of evidence demonstrates a link between disturbances in mitochondrial functioning, insulin resistance and diabetes. In particular, mitochondrial function is required for appropriate glucose-induced insulin secretion. In addition, statins provoke myalgias, often exacerbated by exercise, resulting in reduced physical activity which in turn increases insulin resistance and the risk of type 2 diabetes. It is, therefore, not unexpected that statins increase both insulin resistance and the risk of new-onset type 2 diabetes.
Formal Description
Interaction-ID: 39014

phenotype

myalgia

increases_activity of

phenotype

decreased physical activity