General Information:

Id: 3,872 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mammalia
review
Reference: de Lorgeril M et al.(2013) Recent findings on the health effects of omega-3 fatty acids and statins, and their interactions: do statins inhibit omega-3 BMC Med 11: 5 [PMID: 23289647]

Interaction Information:

Comment Early randomized controlled trials (RCTs) demonstrated the health benefits of omega-3 fatty acids (n-3), whereas recent RCTs were negative. Most patients in recent RCTs are no longer n-3 deficient and the vast majority are now treated with statins. Recent RCTs testing n-3 against arrhythmias suggest that n-3 reduce the risk only in patients not taking a statin. Other recent RCTs in secondary prevention were negative although, in a post-hoc analysis separating statin users and non-users, non-significant protection of n-3 was observed among statin non-users whereas statin users had no effect. Recent RCTs testing statins - after the implementation of the New Clinical Trial Regulation in 2007 - are negative (or flawed) suggesting that the lack of effect of n-3 cannot be attributed to a parallel protection by statins.
Formal Description
Interaction-ID: 38984

drug/chemical compound

Statin

affects_activity of

drug/chemical compound

Polyunsaturated fatty acid, omega-3

Comment It has been shown, including in an randomized controlled trials (RCT) in coronary heart disease (CHD) patients, that statins increase arachidonic acid, the main n-6 fatty acid in cell membranes.
Formal Description
Interaction-ID: 38996

drug/chemical compound

Statin

increases_quantity of

drug/chemical compound

Arachidonic acid

Drugbank entries Show/Hide entries for
Comment A second mechanism would be through alteration of mitochondrial function, a key component of myocardial preconditioning. Chronic myocardial preconditioning, that is, the ability of the myocardium to withstand an ischemia-reperfusion injury and limit the extent of cell death during and after myocardial ischemia, is a major determinant of the outcome of any heart attack. Mitochondria are critical in the induction of myocardial preconditioning, and also of neuroprotection, and n-3 induce a chronic myocardial preconditioning state which is likely explained by 'improved' mitochondrial function. On the other hand, statins are toxic for the mitochondria in a dose-dependent manner and patients treated with statins do have impairment of mitochondrial respiration.
Formal Description
Interaction-ID: 38999

drug/chemical compound

Statin

increases_activity of

Comment In animal experiments, coenzyme Q10, a key component in mitochondrial bioenergy transfer and the synthesis of which is inhibited by statins, was reduced in case of impaired heart mitochondrial function.
Formal Description
Interaction-ID: 39000

drug/chemical compound

Statin

decreases_quantity of

drug/chemical compound

Ubiquinone

Comment In animal experiments, coenzyme Q10, a key component in mitochondrial bioenergy transfer and the synthesis of which is inhibited by statins, was reduced in case of impaired heart mitochondrial function.
Formal Description
Interaction-ID: 39002

drug/chemical compound

Statin

decreases_activity of

Comment Endogenous production of coenzyme Q10 is inhibited by blocking the HMG-CoA reductase enzyme with statins and decreased plasma coenzyme Q10 was confirmed in statin-treated coronary heart disease (CHD) patients.
Formal Description
Interaction-ID: 39007

drug/chemical compound

Statin

decreases_activity of

gene/protein

HMGCR

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Comment A growing body of evidence demonstrates a link between disturbances in mitochondrial functioning, insulin resistance and diabetes. In particular, mitochondrial function is required for appropriate glucose-induced insulin secretion. In addition, statins provoke myalgias, often exacerbated by exercise, resulting in reduced physical activity which in turn increases insulin resistance and the risk of type 2 diabetes. It is, therefore, not unexpected that statins increase both insulin resistance and the risk of new-onset type 2 diabetes.
Formal Description
Interaction-ID: 39013

drug/chemical compound

Statin

increases_activity of

phenotype

myalgia

exacerbated by exercise
Comment A growing body of evidence demonstrates a link between disturbances in mitochondrial functioning, insulin resistance and diabetes. In particular, mitochondrial function is required for appropriate glucose-induced insulin secretion. In addition, statins provoke myalgias, often exacerbated by exercise, resulting in reduced physical activity which in turn increases insulin resistance and the risk of type 2 diabetes. It is, therefore, not unexpected that statins increase both insulin resistance and the risk of new-onset type 2 diabetes.
Formal Description
Interaction-ID: 39014

phenotype

myalgia

increases_activity of

phenotype

decreased physical activity

Comment A growing body of evidence demonstrates a link between disturbances in mitochondrial functioning, insulin resistance and diabetes. In particular, mitochondrial function is required for appropriate glucose-induced insulin secretion. In addition, statins provoke myalgias, often exacerbated by exercise, resulting in reduced physical activity which in turn increases insulin resistance and the risk of type 2 diabetes. It is, therefore, not unexpected that statins increase both insulin resistance and the risk of new-onset type 2 diabetes.
Formal Description
Interaction-ID: 39017

drug/chemical compound

Statin

increases_activity of

disease

Insulin resistance

Comment A growing body of evidence demonstrates a link between disturbances in mitochondrial functioning, insulin resistance and diabetes. In particular, mitochondrial function is required for appropriate glucose-induced insulin secretion. In addition, statins provoke myalgias, often exacerbated by exercise, resulting in reduced physical activity which in turn increases insulin resistance and the risk of type 2 diabetes. It is, therefore, not unexpected that statins increase both insulin resistance and the risk of new-onset type 2 diabetes.
Formal Description
Interaction-ID: 39018

drug/chemical compound

Statin

increases_activity of

Comment The interactions between statins and n-3 may explain why statins decrease memory and energy and also increase fatigue with exertion since n-3 are major lipids of the brain and nervous system.
Formal Description
Interaction-ID: 39026

drug/chemical compound

Statin

decreases_activity of

process

memory

Comment The interactions between statins and n-3 may explain why statins decrease memory and energy and also increase fatigue with exertion since n-3 are major lipids of the brain and nervous system.
Formal Description
Interaction-ID: 39027

drug/chemical compound

Statin

increases_activity of

phenotype

fatigue