General Information:

Id: 3,870 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Huntington disease - [OMIM]
Reference: Ma QL et al.(2012) PAK in Alzheimer disease, Huntington disease and X-linked mental retardation Cell Logist 2: 117-125 [PMID: 23162743]

Interaction Information:

Comment ROCKs can induce the processing of APP to the toxic Abeta (42) species and inhibitors of ROCKs, such as statins and certain NSAIDs (Non-steroid antiinflammatory drugs), can significantly suppress this amyloidogenic APP processing.
Formal Description
Interaction-ID: 39443

drug/chemical compound


decreases_quantity of