General Information:

Id: 386 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Fatty liver disease, nonalcoholic
Insulin resistance
Mus musculus
mouse transduced with adenoviruses expressing either murine mtGPAT (GPAM) or a catalytically inactive variant of the enzyme
Reference: Linden D et al.(2006) Liver-directed overexpression of mitochondrial glycerol-3-phosphate acyltransferase results in hepatic steatosis, increased triacylglycerol secretion and reduced fatty acid oxidation FASEB J. 20: 434-443 [PMID: 16507761]

Interaction Information:

Comment mtGPAT overexpression in vivo specifically increased hepatic TAG and DAG levels and decreased the availability of fatty acids for beta-oxidation.
Formal Description
Interaction-ID: 12707


Mitochondrial GPAT

decreases_activity of

in liver; if mitochondrial GPAT is overexpressed in liver