General Information:

Id: 386 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Fatty liver disease, nonalcoholic
Insulin resistance
Mus musculus
male
mouse transduced with adenoviruses expressing either murine mtGPAT (GPAM) or a catalytically inactive variant of the enzyme
article
Reference: Linden D et al.(2006) Liver-directed overexpression of mitochondrial glycerol-3-phosphate acyltransferase results in hepatic steatosis, increased triacylglycerol secretion and reduced fatty acid oxidation FASEB J. 20: 434-443 [PMID: 16507761]

Interaction Information:

Comment mtGPAT overexpression had no effect on plasma glucose or insulin levels, however both plasma TAG and cholesterol levels were increased (27% and 20%, respectively) after 4 days in mice treated with Ad-mtGPAT compared with Ad-mtGPAT-mut, indicating that the VLDL secretion from the liver may be affected by hepatic mtGPAT overexpression.
Formal Description
Interaction-ID: 12705

gene/protein

Mitochondrial GPAT

affects_quantity of

drug/chemical compound

Cholesterol

in blood; if mitochondrial GPAT is overexpressed in liver
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