General Information:

Id: 386 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Fatty liver disease, nonalcoholic
Insulin resistance
Mus musculus
male
mouse transduced with adenoviruses expressing either murine mtGPAT (GPAM) or a catalytically inactive variant of the enzyme
article
Reference: Linden D et al.(2006) Liver-directed overexpression of mitochondrial glycerol-3-phosphate acyltransferase results in hepatic steatosis, increased triacylglycerol secretion and reduced fatty acid oxidation FASEB J. 20: 434-443 [PMID: 16507761]

Interaction Information:

Comment mtGPAT overexpression did not affect liver content of phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylserine, sphingomyelin, lysolecithin, cholesterol, or CE after 4 or 11 days. These results indicate that hepatic mtGPAT overexpression directs fatty acids into DAG and TAG rather than phospholipids or CE in vivo in mice leading to hepatic steatosis.
Formal Description
Interaction-ID: 12679

gene/protein

Mitochondrial GPAT

NOT affects_quantity of

drug/chemical compound

Cholesterol

in liver; if mitochondrial GPAT is overexpressed in liver
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