General Information:

Id: 385 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Homo sapiens
BTO:0003350 BV-2 cell
article
Reference: Liu Y et al.(2009) Expression of amyotrophic lateral sclerosis-linked SOD1 mutant increases the neurotoxic potential of microglia via TLR2 J. Biol. Chem. 284: 3691-3699 [PMID: 19091752]

Interaction Information:

Comment Mutant SOD1 (G93A or L8Q or G10V) enhances TLR2 stimulation-induced microglial TNF-alpha secretion. Mutant SOD1 (G93A or L8Q or G10V)-overexpressing cells released significantly more TNF-alpha than wtSOD1-overexpressing or mock control cells after TLR2 stimulation. Secretion of IL-6 was reduced. The secretion of IL-1-beta was not significantly increased by the TLR2 stimulation.
Formal Description
Interaction-ID: 1607

gene/protein mutant

SOD1-p.G93A

NOT affects_quantity of

gene/protein

IL1B

in TLR2 stimulated murine microglial cell line BV-2; if mutSOD1 is overexpressed
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