General Information:

Id: 385 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Homo sapiens
BTO:0003350 BV-2 cell
article
Reference: Liu Y et al.(2009) Expression of amyotrophic lateral sclerosis-linked SOD1 mutant increases the neurotoxic potential of microglia via TLR2 J. Biol. Chem. 284: 3691-3699 [PMID: 19091752]

Interaction Information:

Comment Mutant SOD1 (G93A or L8Q or G10V) enhances TLR2 stimulation-induced microglial TNF-alpha secretion. Mutant SOD1 (G93A or L8Q or G10V)-overexpressing cells released significantly more TNF-alpha than wtSOD1-overexpressing or mock control cells after TLR2 stimulation. Secretion of IL-6 was reduced.
Formal Description
Interaction-ID: 1578

gene/protein mutant

SOD1-p.G93A

increases_quantity of

gene/protein

TNF

in TLR2 stimulated murine microglial cell line BV-2; if SOD1(G93A) is overexpressed
Drugbank entries Show/Hide entries for TNF
Comment SOD1 G93A mutation does not enhance transcription of TNF-alpha.
Formal Description
Interaction-ID: 1583

gene/protein mutant

SOD1-p.G93A

NOT increases_expression of

gene/protein

TNF

in TLR2 stimulated murine microglial cell line BV-2; if SOD1(G93A) is overexpressed
Drugbank entries Show/Hide entries for TNF
Comment P47-PHOX mediates SOD1 G93A mutation-enhanced oxidative stress and subsequent TNF-alpha secretion following TLR2 stimulation.
Formal Description
Interaction-ID: 1598

gene/protein

NCF1

affects_quantity of

gene/protein

TNF

in TLR2 stimulated murine microglial cell line BV-2; if SOD1(G93A) is overexpressed
Drugbank entries Show/Hide entries for TNF
Comment Pretreatment of microglial cells with antioxidant regents, e.g. NAC (N-acetyl-L-cysteine) and catalase, before TLR2 stimulation, showed that SOD1 G93A overexpression-associated enhancement of TNF-alpha secretion was reversed.
Formal Description
Interaction-ID: 1599

drug/chemical compound

Acetylcysteine

decreases_quantity of

gene/protein

TNF

in TLR2 stimulated murine microglial cell line BV-2; if SOD1(G93A) is overexpressed
Drugbank entries Show/Hide entries for Acetylcysteine or TNF
Comment ADAM10 and 17 are involved in SOD1 G93A mutation-enhanced TNF-alpha secretion following TLR2 stimulation. Following ADAM10 or ADAM17 gene silencing, the mSOD1(G93A)-induced enhancement of microglial TNF-alpha release was reversed.
Formal Description
Interaction-ID: 1605

gene/protein

ADAM10

affects_quantity of

gene/protein

TNF

in TLR2 stimulated murine microglial cell line BV-2; if SOD1(G93A) is overexpressed
Drugbank entries Show/Hide entries for TNF
Comment ADAM10 and 17 are involved in SOD1 G93A mutation-enhanced TNF-alpha secretion following TLR2 stimulation. Following ADAM10 or ADAM17 gene silencing, the mSOD1(G93A)-induced enhancement of microglial TNF-alpha release was reversed.
Formal Description
Interaction-ID: 1606

gene/protein

ADAM17

affects_quantity of

gene/protein

TNF

in TLR2 stimulated murine microglial cell line BV-2; if SOD1(G93A) is overexpressed
Drugbank entries Show/Hide entries for ADAM17 or TNF