General Information:

Id: 385 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Homo sapiens
BTO:0003350 BV-2 cell
article
Reference: Liu Y et al.(2009) Expression of amyotrophic lateral sclerosis-linked SOD1 mutant increases the neurotoxic potential of microglia via TLR2 J. Biol. Chem. 284: 3691-3699 [PMID: 19091752]

Interaction Information:

Comment Pretreatment of microglial cells with antioxidant regents, e.g. NAC (N-acetyl-L-cysteine) and catalase, before TLR2 stimulation, showed that SOD1 G93A overexpression-associated enhancement of TNF-alpha secretion was reversed.
Formal Description
Interaction-ID: 1599

drug/chemical compound

Acetylcysteine

decreases_quantity of

gene/protein

TNF

in TLR2 stimulated murine microglial cell line BV-2; if SOD1(G93A) is overexpressed
Drugbank entries Show/Hide entries for Acetylcysteine or TNF