General Information:

Id: 3,819 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mammalia
review
Reference: Aguilar D and Solomon SD(2006) ACE inhibitors and angiotensin receptor antagonists and the incidence of new-onset diabetes mellitus: an emerging theme Drugs 66: 1169-1177 [PMID: 16827595]

Interaction Information:

Comment The renin-angiotensin system (RAS) may affect the function of the pancreas. Angiotensin II has been demonstrated to have significant vasoconstrictive effects on the pancreatic vasculature, which may impair blood flow to the pancreas and pancreatic beta-cells. In addition, activation of the RAS within the pancreas and pancreatic islets may lead to expression of enzymes and receptors that lead to a disruption of islet cell architecture, fibrosis and apoptosis. Inhibition of the RAS by ACE inhibitors and ARBs appears to attenuate this fibrotic, destructive response in the islet cells.
Formal Description
Interaction-ID: 38214
Comment Deleterious effects of angiotensin II on the insulin-signaling pathway through the phosphoinositol-3-kinase/protein kinase C signaling pathway in skeletal muscle and cardiovascular tissue also appear to be contributing to insulin resistance.
Formal Description
Interaction-ID: 38219

gene/protein

Angiotensin II

decreases_activity of

in skeletal muscle, in cardiac muscle
Comment Additionally, the RAS may influence insulin sensitivity by affecting adipocyte morphology and function. Angiotensin II has been shown to inhibit the differentiation of preadipocytes to mature adipocytes.
Formal Description
Interaction-ID: 38224

gene/protein

Angiotensin II

decreases_activity of