General Information:

Id: 379 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Mus musculus
SOD1(G93A) transgenic mouse
BTO:0001279 spinal cord
article
Reference: Petri S et al.(2007) The lipophilic metal chelators DP-109 and DP-460 are neuroprotective in a transgenic mouse model of amyotrophic lateral sclerosis J. Neurochem. 102: 991-1000 [PMID: 17630988]

Interaction Information:

Comment Protein expression of TNF-alpha was up-regulated as well in the ventral horn of vehicle-treated G93A but not in DP-109- and DP-460-treated G93A mice as compared with wild-type mice. The lipophilic metal chelators DP-109 and DP-460 are diester derivatives of BAPTA [1,2-bis(2-aminophenyloxy)ethane-N,N,N',N'-tetra acetic acid].
Formal Description
Interaction-ID: 1558

drug/chemical compound

Lipophilic metal chelator DP-109

NOT increases_quantity of

gene/protein

TNF

in SOD1(G93A) transgenic mice
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