CIDeRGeneral Information:
| Id: | 379 (click here to show other Interactions for entry) |
| Diseases: |
Amyotrophic lateral sclerosis
|
| Mus musculus | |
| SOD1(G93A) transgenic mouse | |
| BTO:0001279 spinal cord | |
| article | |
| Reference: | Petri S et al.(2007) The lipophilic metal chelators DP-109 and DP-460 are neuroprotective in a transgenic mouse model of amyotrophic lateral sclerosis J. Neurochem. 102: 991-1000 [PMID: 17630988] |
Interaction Information:
| Comment | Protein expression of TNF-alpha was up-regulated as well in the ventral horn of vehicle-treated G93A but not in DP-109- and DP-460-treated G93A mice as compared with wild-type mice. The lipophilic metal chelators DP-109 and DP-460 are diester derivatives of BAPTA [1,2-bis(2-aminophenyloxy)ethane-N,N,N',N'-tetra acetic acid]. |
|
Formal Description Interaction-ID: 1555 |
gene/protein mutant increases_quantity of gene/protein |
| Drugbank entries | Show/Hide entries for TNF |
| Comment | Protein expression of TNF-alpha was up-regulated as well in the ventral horn of vehicle-treated G93A but not in DP-109- and DP-460-treated G93A mice as compared with wild-type mice. The lipophilic metal chelators DP-109 and DP-460 are diester derivatives of BAPTA [1,2-bis(2-aminophenyloxy)ethane-N,N,N',N'-tetra acetic acid]. |
|
Formal Description Interaction-ID: 1557 |
drug/chemical compound Lipophilic metal chelator DP-460 NOT increases_quantity of gene/protein |
| Drugbank entries | Show/Hide entries for TNF |
| Comment | Protein expression of TNF-alpha was up-regulated as well in the ventral horn of vehicle-treated G93A but not in DP-109- and DP-460-treated G93A mice as compared with wild-type mice. The lipophilic metal chelators DP-109 and DP-460 are diester derivatives of BAPTA [1,2-bis(2-aminophenyloxy)ethane-N,N,N',N'-tetra acetic acid]. |
|
Formal Description Interaction-ID: 1558 |
drug/chemical compound Lipophilic metal chelator DP-109 NOT increases_quantity of gene/protein |
| Drugbank entries | Show/Hide entries for TNF |