General Information:

Id: 3,795 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mammalia
review
Reference: Avruch J et al.(2009) Amino acid regulation of TOR complex 1 Am. J. Physiol. Endocrinol. Metab. 4: E592-E602 [PMID: 18765678]

Interaction Information:

Comment As regards the biochemical mechanism by which Rheb activates mTORC1, Rheb does not achieve this effect through modulating amino acid uptake, as overexpressing Rheb (or TSC1/2) has no effect on the steady-state concentration of individual amino acids within the cells, including the concentrations of branched-chain amino acids and arginine.
Formal Description
Interaction-ID: 37738

gene/protein

RHEB

increases_activity of

complex/PPI

mTORC1 complex

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