General Information:

Id: 3,795 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mammalia
review
Reference: Avruch J et al.(2009) Amino acid regulation of TOR complex 1 Am. J. Physiol. Endocrinol. Metab. 4: E592-E602 [PMID: 18765678]

Interaction Information:

Comment Growth factors regulate TORC1 activity via either the PI3K/Akt pathway or the Ras/MAPK pathway, which converge on the tuberous sclerosis heterodimeric complex (TSC1-TSC2) to inhibit, by phosphorylation of TSC2, the GTPase-activating function (GAP activity) toward the small GTPase Rheb (Ras homolog enriched in brain).
Formal Description
Interaction-ID: 37669

complex/PPI

TSC1-TSC2 complex

decreases_activity of

complex/PPI

mTORC1 complex

Comment As regards the biochemical mechanism by which Rheb activates mTORC1, Rheb does not achieve this effect through modulating amino acid uptake, as overexpressing Rheb (or TSC1/2) has no effect on the steady-state concentration of individual amino acids within the cells, including the concentrations of branched-chain amino acids and arginine.
Formal Description
Interaction-ID: 37738

gene/protein

RHEB

increases_activity of

complex/PPI

mTORC1 complex

Drugbank entries Show/Hide entries for RHEB