General Information:

Id: 3,794 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Rattus norvegicus
male
Zucker fatty (fa/fa) and lean (fa/+) rats
article
Reference: Hsiao G et al.(2011) Multi-tissue, selective PPARgamma modulation of insulin sensitivity and metabolic pathways in obese rats Am. J. Physiol. Endocrinol. Metab. 300: E164-E174 [PMID: 20959535]

Interaction Information:

Comment The PPARgamma ligand treatments also induced expression of slow-twitch muscle fiber markers in skeletal muscle profiles, including the three troponin subunits specific for slow-twitch skeletal muscle (Tnnc1, Tnni1, Tnnt1) and the slow-twitch type I fiber type-specific myosin heavy-chain 7 (Myh7). Two genes involved in calcium transport and binding in the sarcoplasmic reticulum of slow-twitch fiber types (Atp2a2, Casq2) were also upregulated after PPARgamma ligand treatment. The slow-twitch muscle markers tended to be overexpressed in the fatty control (FC) vs. lean control (LC) rats, but this did not exceed the stringent significance thresholds. Tnnc1 and Tnni1 exhibited ligand treatment-selective modulation, which was not correlated with ligand treatment insulin-sensitizing potency. Overall, the observations in skeletal muscle profiles suggest that insulin resistance is associated with moderate remodeling of the skeletal muscle, involving increased adiposity and slow-twitch muscle fibers, and that this remodeling is further amplified after PPARgamma ligand treatment.
Formal Description
Interaction-ID: 37599

drug/chemical compound

Thiazolidinedione

increases_expression of

gene/protein

TNNI1

in skeletal muscle