General Information:

Id: 3,794 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Rattus norvegicus
male
Zucker fatty (fa/fa) and lean (fa/+) rats
article
Reference: Hsiao G et al.(2011) Multi-tissue, selective PPARgamma modulation of insulin sensitivity and metabolic pathways in obese rats Am. J. Physiol. Endocrinol. Metab. 300: E164-E174 [PMID: 20959535]

Interaction Information:

Comment PPARgamma ligand treatments increase the expression of mitochondria-associated metabolic pathways in adipose tissue. Functional analysis of the genes differentially expressed between fatty control (FC) and PPARgamma ligand-treated rats revealed enrichment for the term 'oxidative phosphorylation' (OXPHOS), represented by 33 upregulated electron transport chain genes.
Formal Description
Interaction-ID: 37534

drug/chemical compound

Thiazolidinedione

increases_expression of

gene/protein

SDHC

in adipose tissue; in obese Zucker rats
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