General Information:

Id: 3,794 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Rattus norvegicus
male
Zucker fatty (fa/fa) and lean (fa/+) rats
article
Reference: Hsiao G et al.(2011) Multi-tissue, selective PPARgamma modulation of insulin sensitivity and metabolic pathways in obese rats Am. J. Physiol. Endocrinol. Metab. 300: E164-E174 [PMID: 20959535]

Interaction Information:

Comment More than 700 genes were selectively modulated by the individual ligand treatments, meaning that their transcriptional responses were significantly different for the different ligand treatments. Functional analysis of this gene set revealed enrichment of many inflammation-related terms including the KEGG pathway term 'cell adhesion molecules' and the ontology term 'immune system process', showing that the PPARgamma ligand treatments modulated these bio-chemical pathways to varying degrees.
Formal Description
Interaction-ID: 37504

drug/chemical compound

Thiazolidinedione

affects_activity of

process

cell adhesion

in adipose tissue