General Information:

Id: 3,794 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Rattus norvegicus
male
Zucker fatty (fa/fa) and lean (fa/+) rats
article
Reference: Hsiao G et al.(2011) Multi-tissue, selective PPARgamma modulation of insulin sensitivity and metabolic pathways in obese rats Am. J. Physiol. Endocrinol. Metab. 300: E164-E174 [PMID: 20959535]

Interaction Information:

Comment PPARgamma ligand treatment of the obese rats induced the differential expression of 732 genes in adipose tissue. Genes downregulated by ligand treatment included immune cell markers (Cd68 and Cd74) and genes involved in macrophage transendothelial infiltration (chemokines Ccl6, Cxcl1, Cxcl12, Cxcl14, and Spp1 aka Opn), cell adhesion (Cd24, Cd44, Icam1, Lsp1), and matrix remodeling (Mmp2). Overexpression of nearly all (43/47) of the immune-related genes in FC rats was decreased in the ligand-treated rats. Of these 43 genes, 36 were normalized to LC group levels.
Formal Description
Interaction-ID: 37492

drug/chemical compound

Thiazolidinedione

decreases_expression of

gene/protein

CD68

in adipose tissue; in obese Zucker rats