General Information:

Id: 3,792 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mammalia
review
Reference: Srikanth V et al.(2011) Advanced glycation endproducts and their receptor RAGE in Alzheimers disease Neurobiol. Aging 32: 763-777 [PMID: 19464758]

Interaction Information:

Comment In AD, most astrocytes contained both AGE- and RAGE-positive granules. In DM patients and control cases, AGE- and RAGE-positive astrocytes were very rare. These findings support the hypothesis that glycated Abeta and RAGE are taken up into astrocytes and degraded through the lysosomal pathway.
Formal Description
Interaction-ID: 37931

drug/chemical compound

Advanced glycation end-product

is localized in

tissue/cell line

astrocyte

in Alzheimer disease in form of granules