General Information:

Id: 3,792 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mammalia
review
Reference: Srikanth V et al.(2011) Advanced glycation endproducts and their receptor RAGE in Alzheimers disease Neurobiol. Aging 32: 763-777 [PMID: 19464758]

Interaction Information:

Comment AGEs could contribute to the inability of microglia to clear plaques by introducing crosslinks to Abeta and other plaque associated proteins which makes it difficult to take up and degrade Abeta by inhibiting lysosomal proteases such as cathepsin D.
Formal Description
Interaction-ID: 37808

drug/chemical compound

Advanced glycation end-product

affects_activity of

tissue/cell line

microglia